Bitter Melon Extract, CAS# 90063-94-8, is a Plant extracts manufactured through plant extraction, available as Brown Yellow fine powder. Bitter Melon Extract is widely used as nutrition supplements. It is widely accepted as safe food additive in many countries.
As Bitter Melon Extract is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Bitter Melon Extract for long period.
Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
There is no evidence that Bitter Melon Extract could have any negative effects on these vulnerable groups. It should be safe to use Bitter Melon Extract in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Bitter Melon Extract for long period in food for newborns or pregnant.
Though Bitter Melon Extract is not on FDA's GRAS exemption list, it's still widely accepted as safe food additive in many countries including USA with specific limit on dosage.
No health issues about Bitter Melon Extract reported up to now.
1. Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice.[Sci Rep. 2013 Nov 5]
Author: Yu Y, Zhang XH, Ebersole B, Ribnicky D, Wang ZQ.
2. Bitter melon extract inhibits proliferation of Trypanosoma brucei bloodstream forms in vitro.[Exp Parasitol. 2013 Mar]
Author: Phillips EA, Sexton DW, Steverding D.
3. Mechanisms underlying decreased hepatic triacylglycerol and cholesterol by dietary bitter melon extract in the rat.[Lipids. 2012 May]
Author: Senanayake GV, Fukuda N, Nshizono S, Wang YM, Nagao K, Yanagita T, Iwamoto M, Ohta H.
4. Bitter melon extract impairs prostate cancer cell-cycle progression and delays prostatic intraepithelial neoplasia in TRAMP model.[Cancer Prev Res (Phila). 2011 Dec]
Author: Ru P, Steele R, Nerurkar PV, Phillips N, Ray RB.
5. A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound.[Biofactors. 2004]
Author: Konishi T, Satsu H, Hatsugai Y, Aizawa K, Inakuma T, Nagata S, Sakuda SH, Nagasawa H, Shimizu M.
